Get a Quote

Spray Drying Pharmaceuticals

At the macrolevel Out of the high demand for pharmaceutical products and the support of advanced technology the global spray drying market in pharmaceutical industry is currently dominated by North America followed by Europe and AsiaThe industry insider believes that due to the improvement of health care facilities increasing research and development and the continuous introduction of government initiatives Brazil Russia China and India will become the fastestgrowing countries in the market of spray drying in pharmaceutical industry.

Aug 14 2018nbsp018332Spray drying plays a crucial role in the processing of pharmaceutical products such as pills capsules and tablets as it is used to convert drug containing liquids into dried powdered formsNano spray drying is in particular used to improve drug formulation by encapsulating active ingredients in polymeric wall materials for protection and.

Development amp Bioavailability187 Catalent Spray Drying TechnologyCatalent Spray Drying Technology.

Drying is a mass transfer process consisting of the removal of water or another solvent by evaporation from a solid semisolid or liquidIn bioproducts like food grains and pharmaceuticals like vaccines the solvent to be removed is almost invariably water.

First invented in 1872 it became widespread during WWII as the dairy industry embraced the process to produce powdered milk for the militaryShortly after spray drying was introduced into drug substance and drug product manufacturingOver time it has been applied in numerous applications for poorly soluble compounds and high drugloaded products.

However compounds with increasingly challenging physical properties such as kinase inhibitors and more demanding target product profiles have brought to light the next generation of spray drying manufacturing challenges.

Jan 30 2021nbsp018332The first commercially available spraydried excipient for direct compression was lactose introduced in 1956 50Spray drying resulted in a final product that comprised 80–90 of αlactose monohydrate crystalline particles agglomerated into spherical units with the aid of the remaining amorphous material.

Jun 09 2020nbsp018332Nextgeneration pharmaceutical spray dryingShepard Associate Principal Engineer and Michael MMorgen Associate Director RampD discuss mechanistic process development with highperformance polymers for bioavailability enhancement.

Shepard Associate Principal Engineer and Michael M.

May 06 2022nbsp018332Spray drying and pharmaceutical applicationsHandbook of pharmaceutical granulation technologyGoogle Scholar Assegehegn G Britode la Fuente E Franco JM Gallegos CFreezedrying A relevant unit operation in the manufacture of foods nutritional products and pharmaceuticalsAdvances in Food and Nutrition Research.

Oct 28 2014nbsp018332Spray drying in the pharmaceutical industry Equipment types and scalesSpray dryers differ in many different ways for example whether or not the drying gasScaleup methodology and process modellingOne particular concern during development of pharmaceutical spray dried.

Once incoming materials arrive at the receiving dock they are typically sampled quarantined until a sample is approved and stored in appropriate warehouse conditionsIncoming materials may come in the form of various dry powders and liquids aqueous andor solventFor large volume applications a facility may employ a liquid tank farm.

Our Bend OR site is our Center of Excellence for solid dispersionsnbsp The site is equipped with a full range of processing capabilities for spray drying as well as hotmelt extrusionnbsp Bend also has extensive capabilities in developing and manufacturing finished drug products in monolithic or multiparticulate formats.

Our SDD technology platform incorporates compositions processes and finished dosage forms designed to meet performance stability and manufacturing requirements for a diverse range of compounds.

quotSpray drying is a single unit operation to rapidly transform liquids into powders in one robust continuous processquot KSpray Drying is a well established and widely used process in many industriesIt takes a pumpable liquid and transforms it into a dry powder.

Pioneered for pharmaceutical applications by Bend Research now Lonza spray drying has emerged as a primary technology for addressing poor dissolution rate solubility and bioavailabilitySpraydried dispersions represent an established approach in bringing an increasing number of BCS II compounds to marketnbsp We have premier expertise and capability in spray drying with integrated capabilities in place to support proofofconcept through commercial scale manufacture of spraydried dispersions or finished drug products based on these intermediates.

Spray drying has a wide range of applications in the pharmaceutical and biotech industryIt is a convenient Review Article method to produce coprocessed excipientsSpray drying is applied to improve the compactability of drugs and to perform microencapsulation granulation and complex formation.

Spray drying in the pharmaceutical industryThe use of spray drying in pharmaceuticals was first explored by Bullock and coworkers in the 1940s and applied to infusions extracts inorganic medicinal salts adrenaline and vitamin CMany more applications followed and particularly relevant was the production of pharmaceutical excipients and.

Spray drying is a method of producing a dry powder from a liquid or slurry by rapidly drying with a hot gasThis is the preferred method of drying of many thermallysensitive materials such as foods and pharmaceuticals.

Spray drying is a rapid robust reproducible and scalable process.

Spray Drying Advantages and Disadvantages.

Spray drying is a semicontinuous process of spraying a liquid solution with dispersed powder into a hot air chamber to evaporate the volatile fraction and produce a very fine powderMost spray drying manufacturing processes are primarily driven by gravity feeding of equipment thus requiring a multilevel throughthefloor tower configurationWhen designing or renovating a spray drying facility there are important considerations throughout the entire process.

Spray drying is a versatile technology that has been applied widely in the chemical food and most recently pharmaceutical industriesThis review focuses on engineering advances and the most significant applications of spray drying for pharmaceuticals.

Spray Drying is an established processing technology for the pharmaceutical industryBy coprecipitating API with a polymer in a stable amorphous solid dispersion spraydrying improves dissolution rates and enhances the bioavailability of poorly soluble compounds.

Summary Spray drying offers multiple opportunities for improving the formulation of both poorly soluble compounds and inhaled drug productsAlthough spray drying is a wellestablished manufacturing process challenges persist throughout the development process and novel applications are continuously evaluatedJoin this webinar to hear from a.

What is spray drying in pharmaceutical industry Spray drying is one of the most remarkable technologies currently to be applied to pharmaceuticalsSpray drying involves the atomisation of a liquid feed into very small droplets within a hot drying gas leading to flash drying of the droplets into solid particles.

Get in Touch

Need more additional information or queries? We are here to help. Please fill in the form below to get in touch.